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Oncolytic adenovirus research evolution: from cell-cycle checkpoints to immune checkpoints

Oncolytic adenoviruses are modified to exploit the aberrant expression of proteins in cancer cells to obtain cancer-selective replication. Moreover, the natural tropism of oncolytic adenoviruses can be redirected to tumor cells. Clinical trials revealed that oncolytic viruses showed poor replication...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Curr Opin Virol
Prif Awduron: Jiang, Hong, Gomez-Manzano, Candelaria, Rivera-Molina, Yisel, Lang, Frederick F., Conrad, Charles A., Fueyo, Juan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550502/
https://ncbi.nlm.nih.gov/pubmed/25863716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coviro.2015.03.009
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