The Prostaglandin E2 Receptor EP4 Regulates Obesity-Related Inflammation and Insulin Sensitivity

With increasing body weight, macrophages accumulate in adipose tissue. There, activated macrophages secrete numerous proinflammatory cytokines and chemokines, giving rise to chronic inflammation and insulin resistance. Prostaglandin E(2) suppresses macrophage activation via EP4; however, the role of...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Yasui, Mika, Tamura, Yukinori, Minami, Manabu, Higuchi, Sei, Fujikawa, Risako, Ikedo, Taichi, Nagata, Manabu, Arai, Hidenori, Murayama, Toshinori, Yokode, Masayuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550358/
https://ncbi.nlm.nih.gov/pubmed/26308623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136304
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