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EP4 signalling is essential for controlling islet inflammation by causing a shift in macrophage polarization in obesity/type 2 diabetes
Activation of the prostaglandin E(2) receptor EP4 alters polarization of adipose tissue macrophages towards the anti-inflammatory M2 phenotype to suppress chronic inflammation. However, the role of EP4 signalling in pancreatic macrophages that affect insulin secretion is unclear. We examined the rol...
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| Publicado no: | Diab Vasc Dis Res |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE Publications
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7510360/ https://ncbi.nlm.nih.gov/pubmed/32722929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1479164120945675 |
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