EP4 signalling is essential for controlling islet inflammation by causing a shift in macrophage polarization in obesity/type 2 diabetes

Activation of the prostaglandin E(2) receptor EP4 alters polarization of adipose tissue macrophages towards the anti-inflammatory M2 phenotype to suppress chronic inflammation. However, the role of EP4 signalling in pancreatic macrophages that affect insulin secretion is unclear. We examined the rol...

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Bibliographic Details
Published in:Diab Vasc Dis Res
Main Authors: Yasui-Kato, Mika, Patlada, Suthomwong, Yokode, Masayuki, Kamei, Kaeko, Minami, Manabu
Format: Artigo
Language:Inglês
Published: SAGE Publications 2020
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7510360/
https://ncbi.nlm.nih.gov/pubmed/32722929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1479164120945675
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