The Prostaglandin E2 Receptor EP4 Regulates Obesity-Related Inflammation and Insulin Sensitivity

With increasing body weight, macrophages accumulate in adipose tissue. There, activated macrophages secrete numerous proinflammatory cytokines and chemokines, giving rise to chronic inflammation and insulin resistance. Prostaglandin E(2) suppresses macrophage activation via EP4; however, the role of...

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Udgivet i:PLoS One
Main Authors: Yasui, Mika, Tamura, Yukinori, Minami, Manabu, Higuchi, Sei, Fujikawa, Risako, Ikedo, Taichi, Nagata, Manabu, Arai, Hidenori, Murayama, Toshinori, Yokode, Masayuki
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550358/
https://ncbi.nlm.nih.gov/pubmed/26308623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136304
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