Self-Assembly of Aβ40, Aβ42 and Aβ43 Peptides in Aqueous Mixtures of Fluorinated Alcohols

Fluorinated alcohols such as hexafluoroisopropanol (HFIP) and trifluoroethanol (TFE) have the ability to promote α-helix and β-hairpin structure in proteins and peptides. HFIP has been used extensively to dissolve various amyloidogenic proteins and peptides including Aβ, in order to ensure their mon...

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Veröffentlicht in:PLoS One
Hauptverfasser: Pachahara, Sanjai Kumar, Adicherla, Harikrishna, Nagaraj, Ramakrishnan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550328/
https://ncbi.nlm.nih.gov/pubmed/26308214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136567
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