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Design, Synthesis, and Antitumor Evaluation of Novel Histone Deacetylase Inhibitors Equipped with a Phenylsulfonylfuroxan Module as a Nitric Oxide Donor

On the basis of the strategy of creating multifunctional drugs, a novel series of phenylsulfonylfuroxan-based hydroxamates with histone deacetylase (HDAC) inhibitory and nitric oxide (NO) donating activities were designed, synthesized, and evaluated. The most potent NO donor–HDAC inhibitor (HDACI) h...

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Опубликовано в: :J Med Chem
Главные авторы: Duan, Wenwen, Li, Jin, Inks, Elizabeth S., Chou, C. James, Jia, Yuping, Chu, Xiaojing, Li, Xiaoyang, Xu, Wenfang, Zhang, Yingjie
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548859/
https://ncbi.nlm.nih.gov/pubmed/25906087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00317
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