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Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity
In our previous study we developed a novel series of tetrahydroisoquinoline-based hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors (Bioorg. Med. Chem., 2010, 18, 1761–1772., J. Med. Chem., 2011, 54, 2823–2838.), among which compound ZYJ-34c (1) was identified and validated as the...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3723752/ https://ncbi.nlm.nih.gov/pubmed/23581848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12144 |
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