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Discovery of the First N-Hydroxycinnamamide-Based Histone Deacetylase 1/3 Dual Inhibitors with Potent Oral Antitumor Activity

[Image: see text] In our previous study, we designed and synthesized a novel series of N-hydroxycinnamamide-based HDAC inhibitors (HDACIs), among which the representative compound 14a exhibited promising HDACs inhibition and antitumor activity. In this current study, we report the development of a m...

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Autors principals: Li, Xiaoyang, Inks, Elizabeth S., Li, Xiaoguang, Hou, Jinning, Chou, C. James, Zhang, Jian, Jiang, Yuqi, Zhang, Yingjie, Xu, Wenfang
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030833/
https://ncbi.nlm.nih.gov/pubmed/24694055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401877m
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