CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability

The CCR4–NOT deadenylase complex plays crucial roles in mRNA decay and translational repression induced by poly(A) tail shortening. Although the in vitro activities of each component of this complex have been well characterized, its in vivo role in immune cells remains unclear. Here we show that mic...

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Foilsithe in:J Exp Med
Main Authors: Inoue, Takeshi, Morita, Masahiro, Hijikata, Atsushi, Fukuda-Yuzawa, Yoko, Adachi, Shungo, Isono, Kyoichi, Ikawa, Tomokatsu, Kawamoto, Hiroshi, Koseki, Haruhiko, Natsume, Tohru, Fukao, Taro, Ohara, Osamu, Yamamoto, Tadashi, Kurosaki, Tomohiro
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548056/
https://ncbi.nlm.nih.gov/pubmed/26238124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150384
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