CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability

The CCR4–NOT deadenylase complex plays crucial roles in mRNA decay and translational repression induced by poly(A) tail shortening. Although the in vitro activities of each component of this complex have been well characterized, its in vivo role in immune cells remains unclear. Here we show that mic...

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Publicado en:J Exp Med
Autores principales: Inoue, Takeshi, Morita, Masahiro, Hijikata, Atsushi, Fukuda-Yuzawa, Yoko, Adachi, Shungo, Isono, Kyoichi, Ikawa, Tomokatsu, Kawamoto, Hiroshi, Koseki, Haruhiko, Natsume, Tohru, Fukao, Taro, Ohara, Osamu, Yamamoto, Tadashi, Kurosaki, Tomohiro
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548056/
https://ncbi.nlm.nih.gov/pubmed/26238124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150384
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