CNOT3 suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins

The CCR4-NOT complex is conserved in eukaryotes and is involved in mRNA metabolism, though its molecular physiological roles remain to be established. We show here that CNOT3-depleted mouse embryonic fibroblasts (MEFs) undergo cell death. Levels of other complex subunits are decreased in CNOT3-deple...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Suzuki, Toru, Kikuguchi, Chisato, Sharma, Sahil, Sasaki, Toshio, Tokumasu, Miho, Adachi, Shungo, Natsume, Tohru, Kanegae, Yumi, Yamamoto, Tadashi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594005/
https://ncbi.nlm.nih.gov/pubmed/26437789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14779
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