Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3(+/−) mice

Obesity is a life-threatening factor and is often associated with dysregulation of gene expression. Here, we show that the CNOT3 subunit of the CCR4–NOT deadenylase complex is critical to metabolic regulation. Cnot3(+/−) mice are lean with hepatic and adipose tissues containing reduced levels of lip...

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Detalhes bibliográficos
Main Authors: Morita, Masahiro, Oike, Yuichi, Nagashima, Takeshi, Kadomatsu, Tsuyoshi, Tabata, Mitsuhisa, Suzuki, Toru, Nakamura, Takahisa, Yoshida, Nobuaki, Okada, Mariko, Yamamoto, Tadashi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243589/
https://ncbi.nlm.nih.gov/pubmed/21897366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.320
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