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RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends
Replication protein A (RPA) is a highly conserved heterotrimeric single-stranded DNA-binding protein involved in DNA replication, recombination, and repair. In fission yeast, the Rpa1-D223Y mutation provokes telomere shortening. Here, we show that this mutation impairs lagging-strand telomere replic...
Guardat en:
| Publicat a: | EMBO J |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley & Sons, Ltd
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4547897/ https://ncbi.nlm.nih.gov/pubmed/26041456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490773 |
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