RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends

Replication protein A (RPA) is a highly conserved heterotrimeric single-stranded DNA-binding protein involved in DNA replication, recombination, and repair. In fission yeast, the Rpa1-D223Y mutation provokes telomere shortening. Here, we show that this mutation impairs lagging-strand telomere replic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO J
Prif Awduron: Audry, Julien, Maestroni, Laetitia, Delagoutte, Emmanuelle, Gauthier, Tiphaine, Nakamura, Toru M, Gachet, Yannick, Saintomé, Carole, Géli, Vincent, Coulon, Stéphane
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley & Sons, Ltd 2015
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547897/
https://ncbi.nlm.nih.gov/pubmed/26041456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490773
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg