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Structure of silent transcription intervals and noise characteristics of mammalian genes

Mammalian transcription occurs stochastically in short bursts interspersed by silent intervals showing a refractory period. However, the underlying processes and consequences on fluctuations in gene products are poorly understood. Here, we use single allele time-lapse recordings in mouse cells to id...

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Detalhes bibliográficos
Publicado no:Mol Syst Biol
Main Authors: Zoller, Benjamin, Nicolas, Damien, Molina, Nacho, Naef, Felix
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547851/
https://ncbi.nlm.nih.gov/pubmed/26215071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20156257
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