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Mechanistic Investigation of the Arrhythmogenic Role of Oxidized CaMKII in the Heart

Oxidative stress and calcium (Ca(2+))/calmodulin (CaM)-dependent protein kinase II (CaMKII) both play important roles in the pathogenesis of cardiac disease. Although the pathophysiological relevance of reactive oxygen species (ROS) and CaMKII has been appreciated for some time, recent work has show...

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Détails bibliographiques
Publié dans:Biophys J
Auteurs principaux: Foteinou, Panagiota T., Greenstein, Joseph L., Winslow, Raimond L.
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547162/
https://ncbi.nlm.nih.gov/pubmed/26287635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.06.064
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