Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts.

The transforming capacity of the normal and mutant human EGF receptor (EGFR) was investigated in primary chicken cells. In fibroblasts, both N- and C-terminal truncations resulted in a weak, additive oncogenic activity. However, not even double truncations caused a v-erbB-like phenotype. Upon EGF-bi...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Khazaie, K, Dull, T J, Graf, T, Schlessinger, J, Ullrich, A, Beug, H, Vennström, B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1988
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC454693/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3263272/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1988.tb03171.x
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