A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation

Fatty acid ethanolamides such as palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) are lipid-derived mediators that potently inhibit pain and inflammation by ligating type-α peroxisome proliferator-activated receptors (PPAR-α). These bioactive substances are preferentially degraded by the cys...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Ribeiro, Alison, Pontis, Silvia, Mengatto, Luisa, Armirotti, Andrea, Chiurchiù, Valerio, Capurro, Valeria, Fiasella, Annalisa, Nuzzi, Andrea, Romeo, Elisa, Moreno-Sanz, Guillermo, Maccarrone, Mauro, Reggiani, Angelo, Tarzia, Giorgio, Mor, Marco, Bertozzi, Fabio, Bandiera, Tiziano, Piomelli, Daniele
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546552/
https://ncbi.nlm.nih.gov/pubmed/25874594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00114
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