Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics

14-3-3 proteins play a pivotal role in controlling cell proliferation and survival, two commonly dysregulated hallmarks of cancers. 14-3-3 protein expression is enhanced in many human cancers and correlates with more aggressive tumors and poor prognosis, suggesting a role for 14-3-3 proteins in tumo...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Woodcock, Joanna M., Coolen, Carl, Goodwin, Katy L., Baek, Dong Jae, Bittman, Robert, Samuel, Michael S., Pitson, Stuart M., Lopez, Angel F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546484/
https://ncbi.nlm.nih.gov/pubmed/25971334
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