β-catenin activation drives thymoma initiation and progression in mice

Thymoma is the most commonly identified cancer in the anterior mediastinum. To date, the causal mechanism that drives thymoma progression is not clear. Here, we generated K5-ΔN64Ctnnb1/ER(T2) transgenic mice, which express an N-terminal deletion mutant of β-catenin fused to a mutated ligand-binding...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Liang, Chih-Chia, Lu, Tsai-Ling, Yu, Yi-Ru, You, Li-Ru, Chen, Chun-Ming
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Priority Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546445/
https://ncbi.nlm.nih.gov/pubmed/26101855
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