Carnosol Inhibits Pro-Inflammatory and Catabolic Mediators of Cartilage Breakdown in Human Osteoarthritic Chondrocytes and Mediates Cross-Talk between Subchondral Bone Osteoblasts and Chondrocytes

AIM: The aim of this work was to evaluate the effects of carnosol, a rosemary polyphenol, on pro-inflammatory and catabolic mediators of cartilage breakdown in chondrocytes and via bone-cartilage crosstalk. MATERIALS AND METHODS: Osteoarthritic (OA) human chondrocytes were cultured in alginate beads...

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Опубликовано в: :PLoS One
Главные авторы: Sanchez, Christelle, Horcajada, Marie-Noëlle, Membrez Scalfo, Fanny, Ameye, Laurent, Offord, Elizabeth, Henrotin, Yves
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546401/
https://ncbi.nlm.nih.gov/pubmed/26292290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136118
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