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Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons
INTRODUCTION: Synaptic dysfunction and intracellular transport defects are early events in Alzheimer’s disease (AD). Extracellular amyloid β (Aβ) oligomers cause spine alterations and impede the transport of proteins and organelles such as brain-derived neurotrophic factor (BDNF) and mitochondria th...
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| Pubblicato in: | Acta Neuropathol Commun |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4546183/ https://ncbi.nlm.nih.gov/pubmed/26293809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0230-2 |
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