Intracellular amyloid β oligomers impair organelle transport and induce dendritic spine loss in primary neurons

INTRODUCTION: Synaptic dysfunction and intracellular transport defects are early events in Alzheimer’s disease (AD). Extracellular amyloid β (Aβ) oligomers cause spine alterations and impede the transport of proteins and organelles such as brain-derived neurotrophic factor (BDNF) and mitochondria th...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Umeda, Tomohiro, Ramser, Elisa M., Yamashita, Minato, Nakajima, Koichi, Mori, Hiroshi, Silverman, Michael A., Tomiyama, Takami
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546183/
https://ncbi.nlm.nih.gov/pubmed/26293809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0230-2
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