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Prevalence of genetic variants of keratins 8 and 18 in patients with drug-induced liver injury
BACKGROUND: Keratin 8 and 18 (K8/K18) cytoskeletal proteins protect hepatocytes from undergoing apoptosis and their mutations predispose to adverse outcomes in acute liver failure (ALF). All known K8/K18 variants occur at relatively non-conserved residues and do not cause keratin cytoskeleton reorga...
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| Veröffentlicht in: | BMC Med |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4545365/ https://ncbi.nlm.nih.gov/pubmed/26286715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-015-0418-0 |
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