Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with JNK activation and protein adduct formation

BACKGROUND AND AIMS: Keratins 8 and 18 (K8/K18) are the intermediate filaments proteins of simple-type digestive epithelia, and provide important cytoprotective function. K8/K18 variants predispose humans to chronic liver disease progression and to poor outcomes in acute acetaminophen (APAP)-related...

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Bibliografski detalji
Izdano u:Hepatology
Glavni autori: Guldiken, Nurdan, Zhou, Qin, Kucukoglu, Ozlem, Rehm, Melanie, Levada, Kateryna, Gross, Annika, Kwan, Raymond, James, Laura P., Trautwein, Christian, Omary, M. Bishr, Strnad, Pavel
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549164/
https://ncbi.nlm.nih.gov/pubmed/25963979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27891
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