Prevalence of genetic variants of keratins 8 and 18 in patients with drug-induced liver injury

BACKGROUND: Keratin 8 and 18 (K8/K18) cytoskeletal proteins protect hepatocytes from undergoing apoptosis and their mutations predispose to adverse outcomes in acute liver failure (ALF). All known K8/K18 variants occur at relatively non-conserved residues and do not cause keratin cytoskeleton reorga...

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Publicat a:BMC Med
Autors principals: Usachov, Valentyn, Urban, Thomas J., Fontana, Robert J., Gross, Annika, Iyer, Sapna, Omary, M. Bishr, Strnad, Pavel
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545365/
https://ncbi.nlm.nih.gov/pubmed/26286715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-015-0418-0
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