Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

The incidence and prevalence of pathological fibrosis increase with advancing age, although mechanisms for this association are unclear. We assessed the capacity for repair of lung injury in young (2 months) and aged (18 months) mice. While the severity of fibrosis was not significantly different be...

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Bibliographic Details
Published in:Sci Transl Med
Main Authors: Hecker, Louise, Logsdon, Naomi J., Kurundkar, Deepali, Kurundkar, Ashish, Bernard, Karen, Hock, Thomas, Meldrum, Eric, Sanders, Yan Y., Thannickal, Victor J.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545252/
https://ncbi.nlm.nih.gov/pubmed/24718857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3008182
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