Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

The incidence and prevalence of pathological fibrosis increase with advancing age, although mechanisms for this association are unclear. We assessed the capacity for repair of lung injury in young (2 months) and aged (18 months) mice. While the severity of fibrosis was not significantly different be...

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Bibliografiske detaljer
Udgivet i:Sci Transl Med
Main Authors: Hecker, Louise, Logsdon, Naomi J., Kurundkar, Deepali, Kurundkar, Ashish, Bernard, Karen, Hock, Thomas, Meldrum, Eric, Sanders, Yan Y., Thannickal, Victor J.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545252/
https://ncbi.nlm.nih.gov/pubmed/24718857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3008182
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