HCN1 Channels Contribute to the Effects of Amnesia and Hypnosis But Not Immobility of Volatile Anesthetics

BACKGROUND: HCN1 channels have been identified as targets of ketamine to produce hypnosis. Volatile anesthetics also inhibit HCN1 channels. However, the effects of HCN1 channels on volatile anesthetics in vivo is still elusive. This study uses global and conditional HCN1 knockout mice to evaluate ho...

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Bibliographic Details
Published in:Anesth Analg
Main Authors: Zhou, Cheng, Liang, Peng, Liu, Jin, Ke, Bowen, Wang, Xiaojia, Li, Fengshan, Li, Tao, Bayliss, Douglas A., Chen, Xiangdong
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4544830/
https://ncbi.nlm.nih.gov/pubmed/26287296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000000830
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