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Forebrain HCN1 channels contribute to hypnotic actions of ketamine

BACKGROUND: Ketamine is a commonly used anesthetic but the mechanistic basis for its clinically relevant actions remains to be determined. We previously showed that HCN1 channels are inhibited by ketamine and demonstrated that global HCN1 knockout mice are two-fold less sensitive to hypnotic actions...

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Bibliographic Details
Main Authors: Zhou, Cheng, Douglas, Jennifer E., Kumar, Natasha N., Shu, Shaofang, Bayliss, Douglas A., Chen, Xiangdong
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605219/
https://ncbi.nlm.nih.gov/pubmed/23377220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e318287b7c8
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