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Forebrain HCN1 channels contribute to hypnotic actions of ketamine

BACKGROUND: Ketamine is a commonly used anesthetic but the mechanistic basis for its clinically relevant actions remains to be determined. We previously showed that HCN1 channels are inhibited by ketamine and demonstrated that global HCN1 knockout mice are two-fold less sensitive to hypnotic actions...

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書誌詳細
主要な著者: Zhou, Cheng, Douglas, Jennifer E., Kumar, Natasha N., Shu, Shaofang, Bayliss, Douglas A., Chen, Xiangdong
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605219/
https://ncbi.nlm.nih.gov/pubmed/23377220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e318287b7c8
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