Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Most genome-wide methylation studies (EWAS) of multifactorial disease traits use targeted arrays or enrichment methodologies preferentially covering CpG-dense regions, to characterize sufficiently large samples. To overcome this limitation, we present here a new customizable, cost-effective approach...

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Pubblicato in:Nat Commun
Autori principali: Allum, Fiona, Shao, Xiaojian, Guénard, Frédéric, Simon, Marie-Michelle, Busche, Stephan, Caron, Maxime, Lambourne, John, Lessard, Julie, Tandre, Karolina, Hedman, Åsa K., Kwan, Tony, Ge, Bing, Rönnblom, Lars, McCarthy, Mark I., Deloukas, Panos, Richmond, Todd, Burgess, Daniel, Spector, Timothy D., Tchernof, André, Marceau, Simon, Lathrop, Mark, Vohl, Marie-Claude, Pastinen, Tomi, Grundberg, Elin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4544751/
https://ncbi.nlm.nih.gov/pubmed/26021296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8211
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