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Gremlin Induces Ocular Hypertension in Mice Through Smad3-Dependent Signaling
PURPOSE: Transforming growth factor–β2 induces extracellular matrix (ECM) remodeling, which likely contributes to the defective function of the trabecular meshwork (TM) leading to glaucomatous ocular hypertension. Bone morphogenetic proteins (BMPs) inhibit these profibrotic effects of TGFβ2. The BMP...
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| Publicado no: | Invest Ophthalmol Vis Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Association for Research in Vision and Ophthalmology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4544199/ https://ncbi.nlm.nih.gov/pubmed/26284554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-16993 |
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