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Gremlin Induces Ocular Hypertension in Mice Through Smad3-Dependent Signaling
PURPOSE: Transforming growth factor–β2 induces extracellular matrix (ECM) remodeling, which likely contributes to the defective function of the trabecular meshwork (TM) leading to glaucomatous ocular hypertension. Bone morphogenetic proteins (BMPs) inhibit these profibrotic effects of TGFβ2. The BMP...
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| Publicado en: | Invest Ophthalmol Vis Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Association for Research in Vision and Ophthalmology
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4544199/ https://ncbi.nlm.nih.gov/pubmed/26284554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-16993 |
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