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Smad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice

TGFβ2 induces extracellular matrix (ECM) remodeling and alters the cytoskeleton by both the canonical Smad and non-canonical signaling pathways. TGFβ2 regulates the expression of ECM proteins in trabecular meshwork (TM) cells, increases intraocular pressure (IOP) in an ex vivo perfusion organ cultur...

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Autors principals: McDowell, Colleen M., Tebow, Holly E., Wordinger, Robert J., Clark, Abbot F.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895953/
https://ncbi.nlm.nih.gov/pubmed/24184030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2013.10.017
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