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Mutant Human Myocilin Induces Strain Specific Differences in Ocular Hypertension and Optic Nerve Damage in Mice

Elevated intraocular pressure (IOP) is a causative risk factor for the development and progression of glaucoma. Glaucomatous mutations in myocilin (MYOC) damage the trabecular meshwork and elevate IOP in humans and in mice. Animal models of glaucoma are important to discover and better understand mo...

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書誌詳細
主要な著者: McDowell, Colleen M., Luan, Tomi, Zhang, Zhang, Putliwala, Tasneem, Wordinger, Robert J., Millar, J. Cameron, John, Simon W.M., Pang, Iok-Hou, Clark, Abbot F.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612883/
https://ncbi.nlm.nih.gov/pubmed/22575566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2012.04.016
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