Mutant Human Myocilin Induces Strain Specific Differences in Ocular Hypertension and Optic Nerve Damage in Mice

Elevated intraocular pressure (IOP) is a causative risk factor for the development and progression of glaucoma. Glaucomatous mutations in myocilin (MYOC) damage the trabecular meshwork and elevate IOP in humans and in mice. Animal models of glaucoma are important to discover and better understand mo...

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Detalhes bibliográficos
Main Authors: McDowell, Colleen M., Luan, Tomi, Zhang, Zhang, Putliwala, Tasneem, Wordinger, Robert J., Millar, J. Cameron, John, Simon W.M., Pang, Iok-Hou, Clark, Abbot F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612883/
https://ncbi.nlm.nih.gov/pubmed/22575566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2012.04.016
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