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Smad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice
TGFβ2 induces extracellular matrix (ECM) remodeling and alters the cytoskeleton by both the canonical Smad and non-canonical signaling pathways. TGFβ2 regulates the expression of ECM proteins in trabecular meshwork (TM) cells, increases intraocular pressure (IOP) in an ex vivo perfusion organ cultur...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3895953/ https://ncbi.nlm.nih.gov/pubmed/24184030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2013.10.017 |
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