A functional deficiency of TERA/VCP/p97 contributes to impaired DNA damage repair in multiple polyglutamine diseases

It is hypothesized that a common underlying mechanism links multiple neurodegenerative disorders. We here show that TERA/VCP/p97 directly binds to multiple polyQ disease proteins (huntingtin, ataxin-1, ataxin-7, and androgen receptor) via polyQ sequence. Although normal and mutant polyQ proteins int...

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Publicado no:Nat Commun
Main Authors: Fujita, Kyota, Nakamura, Yoko, Oka, Tsutomu, Ito, Hikaru, Tamura, Takuya, Tagawa, Kazuhiko, Sasabe, Toshikazu, Katsuta, Asuka, Motoki, Kazumi, Shiwaku, Hiroki, Sone, Masaki, Yoshida, Chisato, Katsuno, Masahisa, Eishi, Yoshinobu, Murata, Miho, Taylor, J. Paul, Wanker, Erich E., Kono, Kazuteru, Tashiro, Satoshi, Sobue, Gen, La Spada, Albert R., Okazawa, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543262/
https://ncbi.nlm.nih.gov/pubmed/23652004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2828
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