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A functional deficiency of TERA/VCP/p97 contributes to impaired DNA damage repair in multiple polyglutamine diseases
It is hypothesized that a common underlying mechanism links multiple neurodegenerative disorders. We here show that TERA/VCP/p97 directly binds to multiple polyQ disease proteins (huntingtin, ataxin-1, ataxin-7, and androgen receptor) via polyQ sequence. Although normal and mutant polyQ proteins int...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4543262/ https://ncbi.nlm.nih.gov/pubmed/23652004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2828 |
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