Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/−) leukemia

BACKGROUND: B-cell precursor acute lymphoblastic leukemia (B-ALL) is amongst the leading causes of childhood cancer-related mortality. Its most common chromosomal aberration is the ETV6-RUNX1 fusion gene, with ~25 % of ETV6-RUNX1 patients also carrying PAX5 alterations. METHODS: We have recreated th...

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Pubblicato in:BMC Cancer
Autori principali: van der Weyden, Louise, Giotopoulos, George, Wong, Kim, Rust, Alistair G., Robles-Espinoza, Carla Daniela, Osaki, Hikari, Huntly, Brian J., Adams, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542115/
https://ncbi.nlm.nih.gov/pubmed/26269126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1586-1
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