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The unfolded protein response in neurodegenerative diseases: a neuropathological perspective
The unfolded protein response (UPR) is a stress response of the endoplasmic reticulum (ER) to a disturbance in protein folding. The so-called ER stress sensors PERK, IRE1 and ATF6 play a central role in the initiation and regulation of the UPR. The accumulation of misfolded and aggregated proteins i...
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| Publicado no: | Acta Neuropathol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4541706/ https://ncbi.nlm.nih.gov/pubmed/26210990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1462-8 |
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