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Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes

Human ageing affects the immune system resulting in an overall decline in immunocompetence. Although all immune cells are affected during aging, the functional capacity of T cells is most influenced and is linked to decreased responsiveness to infections and impaired differentiation. We studied age-...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Tserel, Liina, Kolde, Raivo, Limbach, Maia, Tretyakov, Konstantin, Kasela, Silva, Kisand, Kai, Saare, Mario, Vilo, Jaak, Metspalu, Andres, Milani, Lili, Peterson, Pärt
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4541364/
https://ncbi.nlm.nih.gov/pubmed/26286994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13107
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