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Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes

Human ageing affects the immune system resulting in an overall decline in immunocompetence. Although all immune cells are affected during aging, the functional capacity of T cells is most influenced and is linked to decreased responsiveness to infections and impaired differentiation. We studied age-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Tserel, Liina, Kolde, Raivo, Limbach, Maia, Tretyakov, Konstantin, Kasela, Silva, Kisand, Kai, Saare, Mario, Vilo, Jaak, Metspalu, Andres, Milani, Lili, Peterson, Pärt
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4541364/
https://ncbi.nlm.nih.gov/pubmed/26286994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13107
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