Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.
beta-Amyloid (beta A) is normally produced as a nontoxic soluble peptide. In Alzheimer disease, beta A aggregates and accumulates in the brain as inert diffuse plaques or compact plaques associated with neurodegenerative changes. To determine the relationship of neurotoxicity to the physical state o...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
1994
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45413/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7991613/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.25.12243 |
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