Computational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled Receptors

Allosteric modulators of G protein-coupled receptors (GPCRs), which target at allosteric sites, have significant advantages against the corresponding orthosteric compounds including higher selectivity, improved chemical tractability or physicochemical properties, and reduced risk of receptor oversen...

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Detaylı Bibliyografya
Yayımlandı:AAPS J
Asıl Yazarlar: Feng, Zhiwei, Hu, Guanxing, Ma, Shifan, Xie, Xiang-Qun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer US 2015
Konular:
Review Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540734/
https://ncbi.nlm.nih.gov/pubmed/25940084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9776-y
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