Population Pharmacokinetic Modeling of the Enterohepatic Recirculation of Fimasartan in Rats, Dogs, and Humans

Enterohepatic recirculation (EHC) can greatly enhance plasma drug exposures and therapeutic effects. This study aimed to develop a population pharmacokinetic model that can simultaneously characterize the extent and time-course of EHC in three species using fimasartan, a novel angiotensin II recepto...

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Bibliografiske detaljer
Udgivet i:AAPS J
Main Authors: Kim, Tae Hwan, Shin, Soyoung, Landersdorfer, Cornelia B., Chi, Yong Ha, Paik, Soo Heui, Myung, Jayhyuk, Yadav, Rajbharan, Horkovics-Kovats, Stefan, Bulitta, Jürgen B., Shin, Beom Soo
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540730/
https://ncbi.nlm.nih.gov/pubmed/25990964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9764-2
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