Population Pharmacokinetic Modeling of the Enterohepatic Recirculation of Fimasartan in Rats, Dogs, and Humans

Enterohepatic recirculation (EHC) can greatly enhance plasma drug exposures and therapeutic effects. This study aimed to develop a population pharmacokinetic model that can simultaneously characterize the extent and time-course of EHC in three species using fimasartan, a novel angiotensin II recepto...

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Dades bibliogràfiques
Publicat a:AAPS J
Autors principals: Kim, Tae Hwan, Shin, Soyoung, Landersdorfer, Cornelia B., Chi, Yong Ha, Paik, Soo Heui, Myung, Jayhyuk, Yadav, Rajbharan, Horkovics-Kovats, Stefan, Bulitta, Jürgen B., Shin, Beom Soo
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540730/
https://ncbi.nlm.nih.gov/pubmed/25990964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9764-2
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