Population Pharmacokinetic Modeling of the Enterohepatic Recirculation of Fimasartan in Rats, Dogs, and Humans

Enterohepatic recirculation (EHC) can greatly enhance plasma drug exposures and therapeutic effects. This study aimed to develop a population pharmacokinetic model that can simultaneously characterize the extent and time-course of EHC in three species using fimasartan, a novel angiotensin II recepto...

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Detalhes bibliográficos
Publicado no:AAPS J
Main Authors: Kim, Tae Hwan, Shin, Soyoung, Landersdorfer, Cornelia B., Chi, Yong Ha, Paik, Soo Heui, Myung, Jayhyuk, Yadav, Rajbharan, Horkovics-Kovats, Stefan, Bulitta, Jürgen B., Shin, Beom Soo
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540730/
https://ncbi.nlm.nih.gov/pubmed/25990964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9764-2
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