Population Pharmacokinetic Modeling of the Enterohepatic Recirculation of Fimasartan in Rats, Dogs, and Humans

Enterohepatic recirculation (EHC) can greatly enhance plasma drug exposures and therapeutic effects. This study aimed to develop a population pharmacokinetic model that can simultaneously characterize the extent and time-course of EHC in three species using fimasartan, a novel angiotensin II recepto...

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Dettagli Bibliografici
Pubblicato in:AAPS J
Autori principali: Kim, Tae Hwan, Shin, Soyoung, Landersdorfer, Cornelia B., Chi, Yong Ha, Paik, Soo Heui, Myung, Jayhyuk, Yadav, Rajbharan, Horkovics-Kovats, Stefan, Bulitta, Jürgen B., Shin, Beom Soo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540730/
https://ncbi.nlm.nih.gov/pubmed/25990964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-015-9764-2
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