Aminoglycoside Concentrations Required for Synergy with Carbapenems against Pseudomonas aeruginosa Determined via Mechanistic Studies and Modeling

This study aimed to systematically identify the aminoglycoside concentrations required for synergy with a carbapenem and characterize the permeabilizing effect of aminoglycosides on the outer membrane of Pseudomonas aeruginosa. Monotherapies and combinations of four aminoglycosides and three carbape...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Yadav, Rajbharan, Bulitta, Jürgen B., Schneider, Elena K., Shin, Beom Soo, Velkov, Tony, Nation, Roger L., Landersdorfer, Cornelia B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700360/
https://ncbi.nlm.nih.gov/pubmed/28893782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00722-17
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