Evaluation of Pharmacokinetic/Pharmacodynamic Model-Based Optimized Combination Regimens against Multidrug-Resistant Pseudomonas aeruginosa in a Murine Thigh Infection Model by Using Humanized Dosing Schemes

We previously optimized imipenem and tobramycin combination regimens against a double-resistant clinical Pseudomonas aeruginosa isolate by using in vitro infection models, mechanism-based pharmacokinetic/pharmacodynamic modeling (MBM), and Monte Carlo simulations. The current study aimed to evaluate...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Yadav, Rajbharan, Bulitta, Jürgen B., Wang, Jiping, Nation, Roger L., Landersdorfer, Cornelia B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700304/
https://ncbi.nlm.nih.gov/pubmed/28993331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01268-17
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