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Targeting DOT1L and HOX Gene Expression in MLL-Rearranged Leukemia and Beyond
Leukemias harboring mixed lineage leukemia (MLL1) gene abnormalities are associated with poor clinical outcomes and new therapeutic approaches are desperately needed. Rearrangement of the MLL1 gene generates chimeric proteins that fuse the NH(3)-terminus of MLL1 to the COOH-terminus of its transloca...
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| Published in: | Exp Hematol |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4540610/ https://ncbi.nlm.nih.gov/pubmed/26118503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2015.05.012 |
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