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Targeting DOT1L and HOX Gene Expression in MLL-Rearranged Leukemia and Beyond

Leukemias harboring mixed lineage leukemia (MLL1) gene abnormalities are associated with poor clinical outcomes and new therapeutic approaches are desperately needed. Rearrangement of the MLL1 gene generates chimeric proteins that fuse the NH(3)-terminus of MLL1 to the COOH-terminus of its transloca...

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Detalhes bibliográficos
Publicado no:Exp Hematol
Main Authors: Chen, Chun-Wei, Armstrong, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540610/
https://ncbi.nlm.nih.gov/pubmed/26118503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2015.05.012
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